MLB Players — S
2,188 MLB baseball players with last names starting with S.
- Saalfrank, Andrew 2023–
- Saarloos, Kirk 2002–2008
- Sabathia, CC 2001–2019
- Sabel, Erik 1999–2002
- Saberhagen, Bret 1984–2001
- Sabo, Alex 1936–1937
- Sabo, Chris 1988–1996
- Sabol, Blake 2023–
- Sabrowski, Erik 2024–
- Saccomanno, Mark 2008–2008
- Sacka, Frank 1951–1953
- Sackinsky, Brian 1996–1996
- Sadecki, Ray 1960–1977
- Sadek, Mike 1973–1981
- Sadler, Bill
- Sadler, Billy 2006–2009
- Sadler, Carl 2002–2003
- Sadler, Casey 2014–2021
- Sadler, Donnie 1998–2007
- Sadler, Ray 2005–2005
- Sadowski, Bob 1960–1963
- Sadowski, Ed 1960–1966
- Sadowski, Jim 1974–1974
- Sadowski, Ryan 2009–2009
- Sadowski, Ted 1960–1962
- Sadzeck, Connor 2018–2022
- Saenz, Chris 2004–2004
- Saenz, Olmedo 1994–2007
- Saffell, Tom 1949–1955
- Sage, Harry 1890–1890
- Sager, A. J. 1994–1998
- Sager, Pony 1871–1871
- Saggese, Thomas 2024–
- Sagmoen, Marc 1997–1997
- Saier, Vic 1911–1919
- Sain, Johnny 1942–1955
- Saipe, Mike 1998–1998
- Saito, Takashi 2006–2012
- Sakata, Lenn 1977–1987
- Saladino, Tyler 2015–2019
- Salas, Fernando 2010–2019
- Salas, Juan 2006–2008
- Salas, Marino 2008–2008
- Salas, Mark 1984–1991
- Salas, Wilfredo
- Salazar, Angel 1983–1988
- Salazar, Cándido
- Salazar, César 2023–
- Salazar, Danny 2013–2019
- Salazar, Eduardo 2023–
- Salazar, Jeff 2006–2009
- Salazar, Lázaro
- Salazar, Luis 1980–1992
- Salazar, Oscar 2002–2010
- Salazar, Santiago
- Sale, Chris 2010–
- Sale, Freddy 1924–1924
- Sales, Ed 1890–1890
- Salisbury, Harry 1879–1882
- Salisbury, Solly 1902–1902
- Salkeld, Bill 1945–1950
- Salkeld, Roger 1993–1996
- Sallee, Slim 1908–1921
- Salmon, Brad 2007–2007
- Salmon, Chico 1964–1972
- Salmon, Harry
- Salmon, Roger 1912–1912
- Salmon, Tim 1992–2006
- Salome, Angel 2008–2008
- Saltalamacchia, Jarrod 2007–2018
- Salters, Edward
- Saltzgaver, Jack 1932–1945
- Salvat, Manuel
- Salve, Gus 1908–1908
- Salveson, Jack 1933–1945
- Salvo, Manny 1939–1943
- Samardzija, Jeff 2008–2020
- Sambito, Joe 1976–1987
- Samcoff, Ed 1951–1951
- Samford, Ron 1954–1959
- Sammons, Bryan 2024–
- Sammons, Clint 2007–2009
- Sampen, Bill 1990–1994
- Sample, Billy 1978–1986
- Sampson, Adrian 2016–2022
- Sampson, Benj 1998–1999
- Sampson, Chris 2006–2010
- Sampson, Emanuel
- Sampson, Keyvius 2015–2016
- Sampson, Ormond
- Sampson, Tommy
- Samuel, Amado 1962–1964
- Samuel, Juan 1983–1998
- Samuels, Ike 1895–1895
- Samuels, Joe 1930–1930
- Samuels, Roger 1988–1989
- San, Pedro
- Sanabia, Alex 2010–2013
- Sanabria, Carlos 2020–2020
- Sanches, Brian 2006–2012
- Sanchez, Aaron 2014–2022
- Sanchez, Adrian 2017–2021
- Sanchez, Alejandro 1982–1987
- Sanchez, Alex 1989–1989
- Sanchez, Ali 2020–
- Sanchez, Angel 2006–2013
- Sanchez, Anibal 2006–2022
- Sanchez, Carlos 2014–2022
- Sanchez, Celerino 1972–1973
- Sanchez, Cristopher 2021–
- Sanchez, Duaner 2002–2009
- Sanchez, Eduardo 2011–2013
- Sanchez, Felix 2003–2003
- Sanchez, Freddy 2002–2011
- Sanchez, Gaby 2008–2014
- Sanchez, Gary 2015–
- Sanchez, Hector 2011–2017
- Sanchez, Humberto 2008–2008
- Sanchez, Israel 1988–1990
- Sanchez, Jesus 1998–2004
- Sanchez, Jonathan 2006–2013
- Sanchez, Luis 1981–1985
- Sanchez, Miguel 2021–2022
- Sanchez, Orlando 1981–1984
- Sanchez, Raul 1952–1960
- Sanchez, Rey 1991–2005
- Sanchez, Ricardo 2020–2020
- Sanchez, Romulo 2007–2010
- Sanchez, Sixto 2020–
- Sanchez, Tony 2013–2017
- Sánchez, Gonzalo
- Sand, Heinie 1923–1928
- Sandberg, Gus 1923–1924
- Sandberg, Jared 2001–2003
- Sandberg, Ryne 1981–1997
- Sanders, Anthony 1999–2001
- Sanders, Ben 1888–1892
- Sanders, Cam 2025–
- Sanders, David 2003–2005
- Sanders, Dee 1945–1945
- Sanders, Deion 1989–2001
- Sanders, John 1965–1965
- Sanders, Ken 1964–1976
- Sanders, Leo
- Sanders, Phoenix 2022–2022
- Sanders, Ray 1942–1949
- Sanders, Reggie 1974–1974
- Sanders, Roy 1917–1918
- Sanders, Scott 1993–1999
- Sanders, War 1903–1904
- Sanderson, John
- Sanderson, Scott 1978–1996
- Sandlin, Nick 2021–
- Sandlock, Mike 1942–1953
- Sandoval, Danny 2005–2006
- Sandoval, Freddy 2008–2009
- Sandoval, Pablo 2008–2021
- Sandoval, Patrick 2019–
- Sandridge, Jayvien 2025–
- Sands, Charlie 1967–1975
- Sands, Cole 2022–
- Sands, Donny 2022–2022
- Sands, Jerry 2011–2016
- Sandt, Tommy 1975–1976
- Sanford, Chance 1998–1999
- Sanford, Fred 1943–1951
- Sanford, Jack 1940–1946
- Sanford, Mo 1991–1995
- Sanguillen, Manny 1967–1980
- Sanicki, Ed 1949–1951
- Sanit, Amauri 2011–2011
- Sankey, Ben 1929–1931
- Sanmartin, Reiver 2021–
- Sano, Miguel 2015–
- Sanoja, Javier 2024–
- Santa Cruz, Esteban
- Santaella, Anastasio
- Santana, Andres 1990–1990
- Santana, Carlos 2010–
- Santana, Danny 2014–2021
- Santana, Dennis 2018–
- Santana, Domingo 2014–2020
- Santana, Edgar 2017–2021
- Santana, Ervin 2005–2021
- Santana, Johan 2000–2012
- Santana, Julio 1997–2006
- Santana, Marino 1998–1999
- Santana, Pedro 2001–2001
- Santana, Rafael 1983–1990
- Santander, Anthony 2017–
- Santangelo, F. P. 1995–2001
- Santiago, Benito 1986–2005
- Santiago, Carlos
- Santiago, Hector 2011–2021
- Santiago, Jose 1963–1970
- Santiago, Ramon 2002–2014
- Santillan, Tony 2021–
- Santo, Ron 1960–1974
- Santo Domingo, Rafael 1979–1979
- Santop, Louis
- Santorini, Al 1968–1973
- Santos, Angel 2001–2003
- Santos, Antonio 2020–2021
- Santos, Chad 2006–2006
- Santos, Francisco 2003–2003
- Santos, Gregory 2021–
- Santos, Luis 2017–2018
- Santos, Omir 2008–2013
- Santos, Sergio 2010–2015
- Santos, Victor 2001–2007
- Santovenia, Nelson 1987–1993
- Santry, Edward 1884–1884
- Sappelt, Dave 2011–2013
- Sardinas, Luis 2014–2018
- Sardinha, Bronson 2007–2007
- Sardinha, Dane 2003–2011
- Sarfate, Dennis 2006–2009
- Sargent, Joe 1921–1921
- Sarmiento, Manny 1976–1983
- Sarni, Bill 1951–1956
- Sarvis, Andy
- Sasaki, Kazuhiro 2000–2003
- Sasaki, Roki 2025–
- Sasser, Mackey 1987–1995
- Sasser, Rob 1998–1998
- Satin, Josh 2011–2014
- Satriano, Tom 1961–1970
- Satterfield, Alf
- Saturria, Luis 2000–2001
- Saucedo, Tayler 2021–
- Saucier, Frank 1951–1951
- Saucier, Kevin 1978–1982
- Sauer, Ed 1943–1949
- Sauer, Hank 1941–1959
- Sauer, Matt 2024–
- Sauerbeck, Scott 1999–2006
- Saulter,
- Saunders, Augustus
- Saunders, Bob
- Saunders, Clifford
- Saunders, Dennis 1970–1970
- Saunders, Doug 1993–1993
- Saunders, Joe 2005–2014
- Saunders, Michael 2009–2017
- Saunders, Rusty 1927–1927
- Saunders, Tony 1997–1999
- Saupold, Warwick 2016–2018
- Sauter, Al 1890–1890
- Sauveur, Rich 1986–2000
- Savage, Bob 1942–1949
- Savage, Don 1944–1945
- Savage, Jack 1987–1990
- Savage, Jim
- Savage, Jimmie 1912–1915
- Savage, Junius
- Savage, Ted 1962–1971
- Saverine, Bob 1959–1967
- Savery, Joe 2011–2014
- Savidge, Don 1929–1929
- Savidge, Ralph 1908–1909
- Savransky, Moe 1954–1954
- Sawamura, Hirokazu 2021–2022
- Sawatski, Carl 1948–1963
- Sawyer, Carl 1915–1916
- Sawyer, Eddie
- Sawyer, Rick 1974–1977
- Sawyer, Will 1883–1883
- Sax, Dave 1982–1987
- Sax, Ollie 1928–1928
- Sax, Steve 1981–1994
- Saxon, Thomas
- Say, Jimmy 1882–1887
- Say, Lou 1873–1884
- Sayles, Bill 1939–1943
- Saylor, Alfred
- Saylor, Phil 1891–1891
- Sborz, Jay 2010–2010
- Sborz, Josh 2019–
- Scahill, Rob 2012–2018
- Scala, Jerry 1948–1950
- Scales, Bobby 2009–2010
- Scales, George
- Scales, Junior
- Scalzi, Johnny 1931–1931
- Scalzi, Skeeter 1939–1939
- Scanlan, Bob 1991–2001
- Scanlan, Doc 1903–1911
- Scanlan, Frank 1909–1909
- Scanlan, Mort 1890–1890
- Scanlon, Mike
- Scanlon, Pat 1884–1884
- Scantlebury, Patricio 1956–1956
- Scarbery, Randy 1979–1980
- Scarborough, Ray 1942–1953
- Scarce, Mac 1972–1978
- Scarritt, Russ 1929–1932
- Scarsella, Les 1935–1940
- Scarsone, Steve 1992–1999
- Sceroler, Mac 2021–2021
- Schaal, Paul 1964–1974
- Schacht, Al 1919–1921
- Schacht, Sid 1950–1951
- Schacker, Hal 1945–1945
- Schaefer, Bob
- Schaefer, Germany 1901–1918
- Schaefer, Jeff 1989–1994
- Schaeffer, Harry 1952–1952
- Schaeffer, Jesse
- Schaeffer, Mark 1972–1972
- Schaeffer, Warren
- Schafer, Harry 1871–1878
- Schafer, Jordan 2009–2015
- Schafer, Logan 2011–2016
- Schaffer, Jimmie 1961–1968
- Schaffernoth, Joe 1959–1961
- Schaive, Johnny 1958–1963
- Schalk, Ray 1912–1929
- Schalk, Roy 1932–1945
- Schall, Gene 1995–1996
- Schaller, Walter 1911–1913
- Schallock, Art 1951–1955
- Schang, Bobby 1914–1927
- Schang, Wally 1913–1931
- Schanuel, Nolan 2023–
- Schanz, Charley 1944–1950
- Schappert, John 1882–1882
- Schardt, Bill 1911–1912
- Scharein, Art 1932–1934
- Scharein, George 1937–1940
- Scharf, Nick 1882–1883
- Schattinger, Jeff 1981–1981
- Schatzeder, Dan 1977–1991
- Schauer, Rube 1913–1917
- Schebler, Scott 2015–2021
- Scheer, Al 1913–1915
- Scheer, Heinie 1922–1923
- Scheeren, Fritz 1914–1915
- Scheetz, Owen 1943–1943
- Scheffer, Aaron 1999–1999
- Scheffing, Bob 1941–1951
- Scheffler, Ted 1888–1890
- Schegg, Lefty 1912–1912
- Scheib, Carl 1943–1954
- Scheibeck, Frank 1887–1906
- Scheible, Jack 1893–1894
- Scheid, Rich 1992–1995
- Scheinblum, Richie 1965–1974
- Schell, Danny 1954–1955
- Schelle, Jim 1939–1939
- Schellhase, Al 1890–1891
- Schemanske, Fred 1923–1923
- Schemer, Mike 1945–1946
- Schenck, Bill 1882–1885
- Scheneberg, John 1913–1920
- Schenz, Hank 1946–1951
- Schepner, Joe 1919–1919
- Scheppers, Tanner 2012–2017
- Scherbarth, Bob 1950–1950
- Scherer, Harry 1889–1889
- Scherman, Fred 1969–1976
- Scherrer, Bill 1982–1988
- Scherzer, Max 2008–
- Schesler, Dutch 1931–1931
- Schettler, Lou 1910–1910
- Schiappacasse, Lou 1902–1902
- Schick, Morrie 1917–1917
- Schierholtz, Nate 2007–2014
- Schilling, Chuck 1961–1965
- Schilling, Curt 1988–2007
- Schillings, Red 1922–1922
- Schimpf, Ryan 2016–2018
- Schindler, Bill 1920–1920
- Schiraldi, Calvin 1984–1991
- Schirick, Dutch 1914–1914
- Schlafly, Larry 1902–1914
- Schlei, Admiral 1904–1911
- Schlereth, Daniel 2009–2012
- Schlesinger, Bill 1965–1965
- Schlichting, Travis 2009–2010
- Schliebner, Dutch 1923–1923
- Schlitter, Brian 2010–2019
- Schlittler, Cam 2025–
- Schlitzer, Victor 1908–1914
- Schlosser, Gus 2014–2014
- Schlueter, Jay 1971–1971
- Schlueter, Norm 1938–1944
- Schmack, Brian 2003–2003
- Schmandt, Ray 1915–1922
- Schmees, George 1952–1952
- Schmelz, Al 1967–1967
- Schmelz, Gus
- Schmidt, Bob 1958–1965
- Schmidt, Boss 1906–1911
- Schmidt, Charles 1909–1915
- Schmidt, Clarke 2020–
- Schmidt, Curt 1995–1995
- Schmidt, Dave 1981–1992
- Schmidt, Freddy 1944–1947
- Schmidt, Henry 1903–1903
- Schmidt, Jason 1995–2009
- Schmidt, Jeff 1996–1996
- Schmidt, Konrad 2010–2012
- Schmidt, Mike 1972–1989
- Schmidt, Pete 1913–1913
- Schmidt, Walter 1916–1925
- Schmidt, Willard 1952–1959
- Schmit, Crazy 1890–1901
- Schmitt, Casey 2023–
- Schmitz, Johnny 1941–1956
- Schmoll, Steve 2005–2005
- Schmulbach, Hank 1943–1943
- Schmutz, Charlie 1914–1915
- Schneck, Dave 1972–1974
- Schneemann, Daniel 2024–
- Schneiberg, Frank 1910–1910
- Schneider, Brian 2000–2012
- Schneider, Dan 1963–1969
- Schneider, Davis 2023–
- Schneider, Jeff 1981–1981
- Schneider, John
- Schneider, Pete 1914–1919
- Schnell, Karl 1922–1923
- Schoen, Gerry 1968–1968
- Schoendienst, Red 1945–1963
- Schoeneck, Jumbo 1884–1889
- Schoeneweis, Scott 1999–2010
- Schofield, Dick 1953–1971
- Scholtens, Jesse 2023–2023
- Schomberg, Otto 1886–1888
- Schooler, Mike 1988–1993
- Schoonmaker, Jerry 1955–1957
- Schoop, Jonathan 2013–
- Schorr, Ed 1915–1915
- Schott, Gene 1935–1939
- Schourek, Pete 1991–2001
- Schramka, Paul 1953–1953
- Schrecongost, Ossee 1897–1908
- Schreiber, Barney 1911–1911
- Schreiber, Hank 1914–1926
- Schreiber, John 2019–
- Schreiber, Paul 1922–1945
- Schreiber, Ted 1963–1963
- Schrenk, Steve 1999–2000
- Schriver, Pop 1886–1901
- Schrock, Max 2020–2022
- Schroder, Bob 1965–1968
- Schroder, Chris 2006–2008
- Schroeder, Bill 1983–1990
- Schroll, Al 1958–1961
- Schrom, Ken 1980–1987
- Schu, Rick 1984–1996
- Schuble, Heinie 1927–1936
- Schueler, Ron 1972–1979
- Schuemann, Max 2024–
- Schuerholz, John
- Schugel, A. J. 2015–2017
- Schuler, Dave 1979–1985
- Schullstrom, Erik 1994–1995
- Schulmerich, Wes 1931–1934
- Schult, Art 1953–1960
- Schulte, Frank 1904–1918
- Schulte, Fred 1927–1937
- Schulte, Ham 1940–1940
- Schulte, Jack 1906–1906
- Schulte, Johnny 1923–1932
- Schulte, Len 1944–1946
- Schultz, Barney 1955–1965
- Schultz, Bo 2014–2016
- Schultz, Bob 1951–1955
- Schultz, Buddy 1975–1979
- Schultz, Howie 1943–1948
- Schultz, Jaime 2018–2019
- Schultz, Joe 1912–1925
- Schultz, John 1891–1891
- Schultz, Mike 1947–1947
- Schultz, Paxton 2025–
- Schultz, Webb 1924–1924
- Schulz, Al 1912–1916
- Schulz, Jeff 1989–1991
- Schulz, Walt 1920–1920
- Schulze, Don 1983–1989
- Schulze, John 1891–1891
- Schumacher, Hal 1931–1946
- Schumaker, Skip 2005–2015
- Schumann, Hack 1906–1906
- Schunk, Aaron 2024–
- Schupp, Ferdie 1913–1922
- Schurr, Wayne 1964–1964
- Schuster, Bill 1937–1945
- Schuster, Patrick 2016–2016
- Schutz, Carl 1996–1996
- Schwabe, Mike 1989–1990
- Schwall, Don 1961–1967
- Schwamb, Ralph 1948–1948
- Schwarber, Kyle 2015–
- Schwartz, Bill 1883–1884
- Schwartz, Randy 1965–1966
- Schwarz, Jeff 1993–1994
- Schweitzer, Al 1908–1911
- Schwellenbach, Spencer 2024–
- Schwenck, Rudy 1909–1909
- Schwenk, Hal 1913–1913
- Schwert, Pi 1914–1915
- Schwimer, Michael 2011–2012
- Schwind, Art 1912–1912
- Schwindel, Frank 2019–2022
- Schwinden, Chris 2011–2012
- Schypinski, Jerry 1955–1955
- Scioscia, Mike 1980–1992
- Scoffic, Lou 1936–1936
- Scoggins, Jim 1913–1913
- Sconiers, Daryl 1981–1985
- Score, Herb 1955–1962
- Scotland, Joe
- Scott, 1884–1884
- Scott, Bill
- Scott, Bob
- Scott, Bobby
- Scott, Christian 2024–
- Scott, Darryl 1993–1993
- Scott, Death Valley
- Scott, Dick 1901–1901
- Scott, Donnie 1983–1991
- Scott, Ed 1900–1901
- Scott, Eugene
- Scott, Everett 1914–1926
- Scott, Gary 1991–1992
- Scott, George 1920–1920
- Scott, Jack 1916–1929
- Scott, Jim 1909–1917
- Scott, Joe
- Scott, Joe Burt
- Scott, John 1914–1914
- Scott, Johnie
- Scott, LeGrant 1939–1939
- Scott, Lloyd
- Scott, Luke 2005–2013
- Scott, Marshall 1945–1945
- Scott, Mickey 1972–1977
- Scott, Mike 1979–1991
- Scott, Milt 1882–1886
- Scott, Pete 1926–1928
- Scott, Robby 2016–2019
- Scott, Rodney 1975–1982
- Scott, Tanner 2017–
- Scott, Tayler 2019–
- Scott, Tim 1991–1997
- Scott, Tony 1973–1984
- Scott, Victor 2024–
- Scranton, Jim 1984–1985
- Scribner, Evan 2011–2017
- Scribner, Troy 2017–2018
- Scrivener, Chuck 1975–1977
- Scroggins, Johnnie
- Scrubb, Andre 2020–2021
- Scruggs, Tony 1991–1991
- Scruggs, Xavier 2014–2016
- Scudder, Scott 1989–1993
- Scurry, Rod 1980–1988
- Scutaro, Marco 2002–2014
- Seabol, Scott 2001–2005
- Seabold, Connor 2021–
- Seager, Corey 2015–
- Seager, Kyle 2011–2021
- Seagle, Chandler 2023–2023
- Seale, Johnnie 1964–1965
- Seaman, Kim 1979–1980
- Seanez, Rudy 1989–2008
- Searage, Ray 1981–1990
- Searcy, Steve 1988–1992
- Sears, JP 2022–
- Sears, Ken 1943–1946
- Sears, Todd 2002–2003
- Seaton, Tom 1912–1917
- Seats, Tom 1940–1945
- Seaver, Tom 1967–1986
- Seay, Bobby 2001–2009
- Seay, Dick
- Sebra, Bob 1985–1990
- Sebring, Jimmy 1902–1909
- Sechrist, Doc 1899–1899
- Secory, Frank 1940–1946
- Secrist, Don 1969–1970
- Seddon, Chris 2007–2012
- Sedgwick, Duke 1921–1923
- Sedlacek, Shawn 2002–2002
- Sedlock, Cody 2022–2022
- See, Charlie 1919–1921
- See, Larry 1986–1988
- Seeds, Bob 1930–1940
- Seelbach, Chris 2000–2001
- Seelbach, Chuck 1971–1974
- Seerey, Pat 1943–1949
- Seery, Emmett 1884–1892
- Sefcik, Kevin 1995–2001
- Segedin, Rob 2016–2017
- Segelke, Herman 1982–1982
- Segovia, Zack 2007–2009
- Segraves, J. C.
- Segraves, Sam
- Segrist, Kal 1952–1955
- Segui, David 1990–2004
- Segui, Diego 1962–1977
- Seguignol, Fernando 1998–2003
- Segura, Jean 2012–2023
- Segura, Jose 1988–1991
- Seibel, Phil 2004–2004
- Seibert, Kurt 1979–1979
- Seibold, Socks 1915–1933
- Seigler, Anthony 2025–
- Seilheimer, Ricky 1980–1980
- Seitzer, Kevin 1986–1997
- Selbach, Kip 1894–1906
- Selby, Bill 1996–2003
- Selby, Colin 2023–
- Selden, Bee
- Selden, William
- Sele, Aaron 1993–2007
- Selee, Frank
- Self, Todd 2005–2005
- Selig, Bud
- Selkirk, George 1934–1942
- Sell, Epp 1922–1923
- Sellers,
- Sellers, Jeff 1985–1988
- Sellers, Justin 2011–2014
- Sellers, Rube 1910–1910
- Sellman, Frank 1871–1875
- Sells, Dave 1972–1975
- Selma, Dick 1965–1974
- Selman, Sam 2019–2022
- Selph, Carey 1929–1932
- Selsky, Steve 2016–2017
- Sember, Mike 1977–1978
- Sembera, Carroll 1965–1970
- Semien, Marcus 2013–
- Seminara, Frank 1992–1994
- Seminick, Andy 1943–1957
- Semproch, Ray 1958–1961
- Senerchia, Sonny 1952–1952
- Senga, Kodai 2023–
- Senger, Hayden 2025–
- Sensenderfer, Count 1871–1874
- Sentell, Paul 1906–1907
- Senteney, Steve 1982–1982
- Senzatela, Antonio 2017–
- Senzel, Nick 2019–
- Seo, Jae Weong 2002–2007
- Seoane, Manny 1977–1978
- Sephus, Andrew
- Sepkowski, Ted 1942–1947
- Septimo, Leyson 2012–2012
- Serad, Billy 1884–1888
- Serafini, Dan 1996–2007
- Serena, Bill 1949–1954
- Serna, Paul 1981–1982
- Serrano, Alex 2008–2008
- Serrano, Jimmy 2004–2004
- Serrano, Wascar 2001–2001
- Serrell, Bonnie
- Serum, Gary 1977–1979
- Servais, Scott 1991–2001
- Serven, Brian 2022–
- Service, Scott 1988–2004
- Sessi, Walter 1941–1946
- Settlemire, Merle 1928–1928
- Sevcik, John 1965–1965
- Severeid, Hank 1911–1926
- Severino, Anderson 2022–2022
- Severino, Atahualpa 2011–2011
- Severino, Luis 2015–
- Severino, Pedro 2015–2022
- Severinsen, Al 1969–1972
- Severson, Rich 1970–1971
- Sewald, Paul 2017–
- Seward, Ed 1885–1891
- Seward, Frank 1943–1944
- Seward, George 1875–1882
- Sewell, Joe 1920–1933
- Sewell, Luke 1921–1942
- Sewell, Rip 1932–1949
- Sewell, Tommy 1927–1927
- Sexauer, Elmer 1948–1948
- Sexson, Richie 1997–2008
- Sexton, Chris 1999–2000
- Sexton, Frank 1895–1895
- Sexton, Jimmy 1977–1983
- Sexton, Tom 1884–1884
- Seybold, Socks 1899–1908
- Seyfried, Gordon 1963–1964
- Seymour, Bob 2025–
- Seymour, Carson 2025–
- Seymour, Cy 1896–1913
- Seymour, Ian 2025–
- Seymour, Jake 1882–1882
- Shabala, Adam 2005–2005
- Shackelford, Brian 2005–2006
- Shackelford, John
- Shackelford, Kevin 2017–2018
- Shafer, Justin 2018–2020
- Shafer, Orator 1874–1890
- Shafer, Ralph 1914–1914
- Shafer, Taylor 1884–1890
- Shafer, Tillie 1909–1913
- Shaffer, 1875–1875
- Shaffer, Frank 1884–1884
- Shaffer, John 1886–1887
- Shaffer, Richie 2015–2016
- Shallix, Gus 1884–1885
- Shamberger, Jimmy
- Shamsky, Art 1965–1972
- Shanabrook, Warren 1906–1906
- Shanahan, Greg 1973–1974
- Shaner, Wally 1923–1929
- Shank, Harvey 1970–1970
- Shanks,
- Shanks, Howie 1912–1925
- Shanks, John
- Shanley, Harry 1912–1912
- Shanley, Jim 1876–1876
- Shanner, Bill 1920–1920
- Shannon,
- Shannon, Dan 1889–1891
- Shannon, Frank 1892–1896
- Shannon, Joe 1915–1915
- Shannon, Mike 1962–1970
- Shannon, Owen 1903–1907
- Shannon, Red 1915–1926
- Shannon, Spike 1904–1908
- Shannon, Wally 1959–1960
- Shantz, Billy 1954–1960
- Shantz, Bobby 1949–1964
- Sharman, Ralph 1917–1917
- Sharon, Dick 1973–1975
- Sharp, Bill 1973–1976
- Sharp, Sterling 2020–2020
- Sharpe,
- Sharpe, Bud 1905–1910
- Sharpe, Pepper
- Sharperson, Mike 1987–1995
- Sharpless, Josh 2006–2007
- Sharrott, George 1893–1894
- Sharrott, Jack 1890–1893
- Sharsig, Bill
- Shaughnessy, Shag 1905–1908
- Shaute, Joe 1922–1934
- Shave, Jon 1993–1999
- Shaver, Jeff 1988–1988
- Shaw,
- Shaw, Al 1901–1909
- Shaw, Ben 1917–1918
- Shaw, Bob 1957–1967
- Shaw, Bryan 2011–
- Shaw, Chris 2018–2019
- Shaw, Don 1967–1972
- Shaw, Dupee 1883–1888
- Shaw, Herb
- Shaw, Hunky 1908–1908
- Shaw, Jeff 1990–2001
- Shaw, Jim 1913–1921
- Shaw, Matt 2025–
- Shaw, Robert
- Shaw, Sam 1888–1893
- Shaw, Ted
- Shaw, Travis 2015–2022
- Shawaryn, Mike 2019–2019
- Shawkey, Bob 1913–1927
- Shay, Danny 1901–1907
- Shay, Marty 1916–1924
- Shea, Gerry 1905–1905
- Shea, John 1928–1928
- Shea, Merv 1927–1944
- Shea, Mike 1887–1887
- Shea, Nap 1902–1902
- Shea, Red 1918–1922
- Shea, Spec 1947–1955
- Shea, Steve 1968–1969
- Sheaffer, Danny 1987–1997
- Sheahan, Dan 1884–1884
- Shealy, Al 1928–1930
- Shealy, Ryan 2005–2010
- Shean, Dave 1906–1919
- Shearer, Ray 1957–1957
- Shearn, Tom 2007–2007
- Shearon, John 1891–1896
- Shears, George 1912–1912
- Sheckard, Jimmy 1897–1913
- Sheehan, Emmet 2023–2023
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